small molecule drugs Search Results


hybrid immunocapture lc ms ms  (KCAS Bioanalytical and Biomarker Services)
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KCAS Bioanalytical and Biomarker Services hybrid immunocapture lc ms ms
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small molecule drugs  (Glycomimetics inc)
90
Glycomimetics inc small molecule drugs
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compound library of fda-approved drugs bml-2841-0500  (Enzo Biochem)
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small molecule drug discovery suite 2012  (Schrodinger LLC)
90
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small-molecule drugs  (Calithera inc)
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small-molecule drug ixabepilone  (Alvogen Inc)
90
Alvogen Inc small-molecule drug ixabepilone
The tumor inhibitory effect of anti-PD-1 scFv S12 combined with the small-molecule drug <t>ixabepilone</t> for combination therapy was tested. BALB/c mice with 4T1 allograft tumors established subcutaneously were randomly assigned to four groups ( n = 6 per group) and received the designated treatment. (a) Ixa (ixabepilone) was administered by intravenous injection once a week at a dose of 2.5 mg/kg, whereas scFv S12 was administered via intravenous injection twice a week at a dose of 3 mg/kg. In addition, a group underwent combination therapy with Ixa and scFv S12. The tumor growth curves are presented as the mean ± SD, and the tumor growth inhibition (%TGI) was also calculated. ∗∗ The difference at the level of P < 0.01 was obtained through comparison with the untreated control group. (b) The body weight of the mice was measured once every 7 days, after the antibody was administered, until the experiment concluded. Their body weights are presented as the mean ± SD. (c) Tumors of individual mice were extracted at the end of the experiment for observation of the tumor size.
Small Molecule Drug Ixabepilone, supplied by Alvogen Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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small-molecule characterization  (Genentech inc)
90
Genentech inc small-molecule characterization
The tumor inhibitory effect of anti-PD-1 scFv S12 combined with the small-molecule drug <t>ixabepilone</t> for combination therapy was tested. BALB/c mice with 4T1 allograft tumors established subcutaneously were randomly assigned to four groups ( n = 6 per group) and received the designated treatment. (a) Ixa (ixabepilone) was administered by intravenous injection once a week at a dose of 2.5 mg/kg, whereas scFv S12 was administered via intravenous injection twice a week at a dose of 3 mg/kg. In addition, a group underwent combination therapy with Ixa and scFv S12. The tumor growth curves are presented as the mean ± SD, and the tumor growth inhibition (%TGI) was also calculated. ∗∗ The difference at the level of P < 0.01 was obtained through comparison with the untreated control group. (b) The body weight of the mice was measured once every 7 days, after the antibody was administered, until the experiment concluded. Their body weights are presented as the mean ± SD. (c) Tumors of individual mice were extracted at the end of the experiment for observation of the tumor size.
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small-molecule probe or drug efficacies  (Broad Institute Inc)
90
Broad Institute Inc small-molecule probe or drug efficacies
The tumor inhibitory effect of anti-PD-1 scFv S12 combined with the small-molecule drug <t>ixabepilone</t> for combination therapy was tested. BALB/c mice with 4T1 allograft tumors established subcutaneously were randomly assigned to four groups ( n = 6 per group) and received the designated treatment. (a) Ixa (ixabepilone) was administered by intravenous injection once a week at a dose of 2.5 mg/kg, whereas scFv S12 was administered via intravenous injection twice a week at a dose of 3 mg/kg. In addition, a group underwent combination therapy with Ixa and scFv S12. The tumor growth curves are presented as the mean ± SD, and the tumor growth inhibition (%TGI) was also calculated. ∗∗ The difference at the level of P < 0.01 was obtained through comparison with the untreated control group. (b) The body weight of the mice was measured once every 7 days, after the antibody was administered, until the experiment concluded. Their body weights are presented as the mean ± SD. (c) Tumors of individual mice were extracted at the end of the experiment for observation of the tumor size.
Small Molecule Probe Or Drug Efficacies, supplied by Broad Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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small molecule apis and drug substances  (Cilag AG)
90
Cilag AG small molecule apis and drug substances
The tumor inhibitory effect of anti-PD-1 scFv S12 combined with the small-molecule drug <t>ixabepilone</t> for combination therapy was tested. BALB/c mice with 4T1 allograft tumors established subcutaneously were randomly assigned to four groups ( n = 6 per group) and received the designated treatment. (a) Ixa (ixabepilone) was administered by intravenous injection once a week at a dose of 2.5 mg/kg, whereas scFv S12 was administered via intravenous injection twice a week at a dose of 3 mg/kg. In addition, a group underwent combination therapy with Ixa and scFv S12. The tumor growth curves are presented as the mean ± SD, and the tumor growth inhibition (%TGI) was also calculated. ∗∗ The difference at the level of P < 0.01 was obtained through comparison with the untreated control group. (b) The body weight of the mice was measured once every 7 days, after the antibody was administered, until the experiment concluded. Their body weights are presented as the mean ± SD. (c) Tumors of individual mice were extracted at the end of the experiment for observation of the tumor size.
Small Molecule Apis And Drug Substances, supplied by Cilag AG, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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drug-like small molecules  (Galapagos NV)
90
Galapagos NV drug-like small molecules
The tumor inhibitory effect of anti-PD-1 scFv S12 combined with the small-molecule drug <t>ixabepilone</t> for combination therapy was tested. BALB/c mice with 4T1 allograft tumors established subcutaneously were randomly assigned to four groups ( n = 6 per group) and received the designated treatment. (a) Ixa (ixabepilone) was administered by intravenous injection once a week at a dose of 2.5 mg/kg, whereas scFv S12 was administered via intravenous injection twice a week at a dose of 3 mg/kg. In addition, a group underwent combination therapy with Ixa and scFv S12. The tumor growth curves are presented as the mean ± SD, and the tumor growth inhibition (%TGI) was also calculated. ∗∗ The difference at the level of P < 0.01 was obtained through comparison with the untreated control group. (b) The body weight of the mice was measured once every 7 days, after the antibody was administered, until the experiment concluded. Their body weights are presented as the mean ± SD. (c) Tumors of individual mice were extracted at the end of the experiment for observation of the tumor size.
Drug Like Small Molecules, supplied by Galapagos NV, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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fda-approved and drug-like small molecules preswick  (Biomol GmbH)
90
Biomol GmbH fda-approved and drug-like small molecules preswick
The tumor inhibitory effect of anti-PD-1 scFv S12 combined with the small-molecule drug <t>ixabepilone</t> for combination therapy was tested. BALB/c mice with 4T1 allograft tumors established subcutaneously were randomly assigned to four groups ( n = 6 per group) and received the designated treatment. (a) Ixa (ixabepilone) was administered by intravenous injection once a week at a dose of 2.5 mg/kg, whereas scFv S12 was administered via intravenous injection twice a week at a dose of 3 mg/kg. In addition, a group underwent combination therapy with Ixa and scFv S12. The tumor growth curves are presented as the mean ± SD, and the tumor growth inhibition (%TGI) was also calculated. ∗∗ The difference at the level of P < 0.01 was obtained through comparison with the untreated control group. (b) The body weight of the mice was measured once every 7 days, after the antibody was administered, until the experiment concluded. Their body weights are presented as the mean ± SD. (c) Tumors of individual mice were extracted at the end of the experiment for observation of the tumor size.
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small-molecule senolytic drugs  (Unity Biotechnology)
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Unity Biotechnology small-molecule senolytic drugs
The tumor inhibitory effect of anti-PD-1 scFv S12 combined with the small-molecule drug <t>ixabepilone</t> for combination therapy was tested. BALB/c mice with 4T1 allograft tumors established subcutaneously were randomly assigned to four groups ( n = 6 per group) and received the designated treatment. (a) Ixa (ixabepilone) was administered by intravenous injection once a week at a dose of 2.5 mg/kg, whereas scFv S12 was administered via intravenous injection twice a week at a dose of 3 mg/kg. In addition, a group underwent combination therapy with Ixa and scFv S12. The tumor growth curves are presented as the mean ± SD, and the tumor growth inhibition (%TGI) was also calculated. ∗∗ The difference at the level of P < 0.01 was obtained through comparison with the untreated control group. (b) The body weight of the mice was measured once every 7 days, after the antibody was administered, until the experiment concluded. Their body weights are presented as the mean ± SD. (c) Tumors of individual mice were extracted at the end of the experiment for observation of the tumor size.
Small Molecule Senolytic Drugs, supplied by Unity Biotechnology, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


The tumor inhibitory effect of anti-PD-1 scFv S12 combined with the small-molecule drug ixabepilone for combination therapy was tested. BALB/c mice with 4T1 allograft tumors established subcutaneously were randomly assigned to four groups ( n = 6 per group) and received the designated treatment. (a) Ixa (ixabepilone) was administered by intravenous injection once a week at a dose of 2.5 mg/kg, whereas scFv S12 was administered via intravenous injection twice a week at a dose of 3 mg/kg. In addition, a group underwent combination therapy with Ixa and scFv S12. The tumor growth curves are presented as the mean ± SD, and the tumor growth inhibition (%TGI) was also calculated. ∗∗ The difference at the level of P < 0.01 was obtained through comparison with the untreated control group. (b) The body weight of the mice was measured once every 7 days, after the antibody was administered, until the experiment concluded. Their body weights are presented as the mean ± SD. (c) Tumors of individual mice were extracted at the end of the experiment for observation of the tumor size.

Journal: BioMed Research International

Article Title: Astragalus membranaceus–Derived Anti-Programmed Death-1 Monoclonal Antibodies with Immunomodulatory Therapeutic Effects against Tumors

doi: 10.1155/2020/3415471

Figure Lengend Snippet: The tumor inhibitory effect of anti-PD-1 scFv S12 combined with the small-molecule drug ixabepilone for combination therapy was tested. BALB/c mice with 4T1 allograft tumors established subcutaneously were randomly assigned to four groups ( n = 6 per group) and received the designated treatment. (a) Ixa (ixabepilone) was administered by intravenous injection once a week at a dose of 2.5 mg/kg, whereas scFv S12 was administered via intravenous injection twice a week at a dose of 3 mg/kg. In addition, a group underwent combination therapy with Ixa and scFv S12. The tumor growth curves are presented as the mean ± SD, and the tumor growth inhibition (%TGI) was also calculated. ∗∗ The difference at the level of P < 0.01 was obtained through comparison with the untreated control group. (b) The body weight of the mice was measured once every 7 days, after the antibody was administered, until the experiment concluded. Their body weights are presented as the mean ± SD. (c) Tumors of individual mice were extracted at the end of the experiment for observation of the tumor size.

Article Snippet: Moreover, the small-molecule drug ixabepilone (Alvogen, Inc.) was administered by tail vein i.v. injection once weekly for combined treatment with scFv.

Techniques: Injection, Inhibition, Comparison, Control